Spironolactone is a potent diuretic that it is banned by athletic regulatory agencies, including the NCAA. Spironolactone is prohibited at all times by the World Anti-Doping Agency as a diuretic and masking agent because it will dilute a urine drug tests. Diuretics, which are also known as water pills, have been abused by athletes to dilute urine, increase the rate of weight loss, or mask other prohibited substances in a urine sample.
Spironolactone and Urine Samples