Amphetamine Levels in Chronic Users

Amphetamine levels in chronic users routinely reach higher levels than expected. In people chronically using this medication, total doses are excreted in the urine over several days. Only about 30% of a dose is typically excreted in a 24-hour urine collection. This is highly dependent on the urine pH and can be as high as 74% in acidic urine and as low as 1% in alkaline urine. In other words, over time, the drug slowly accumulates to higher levels than an expected reference range.

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